2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0660R
    Eicosapentaenoic Acid (Standard) 10417-94-4
    Eicosapentaenoic Acid (Standard) is the analytical standard of Eicosapentaenoic Acid. This product is intended for research and analytical applications. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation.
    Eicosapentaenoic Acid (Standard)
  • HY-B0823A
    (E/Z)-Acetamiprid 160430-64-8
    (E/Z)-Acetamiprid is the E/Z mixture of Acetamiprid (HY-B0823). Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders.
    (E/Z)-Acetamiprid
  • HY-B1165R
    Cyproheptadine (hydrochloride sesquihydrate) (Standard) 41354-29-4
    Cyproheptadine (hydrochloride sesquihydrate) (Standard) is the analytical standard of Cyproheptadine (hydrochloride sesquihydrate). This product is intended for research and analytical applications.
    Cyproheptadine (hydrochloride sesquihydrate) (Standard)
  • HY-B1192R
    Estradiol benzoate (Standard) 50-50-0
    Estradiol benzoate (Standard) is the analytical standard of Estradiol benzoate. This product is intended for research and analytical applications. Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice.
    Estradiol benzoate (Standard)
  • HY-B1306R
    4-Aminohippuric acid (Standard) 61-78-9
    4-Aminohippuric acid (p-Aminohippuric acid) (Standard) is the analytical standard of 4-Aminohippuric acid (HY-B1306). This product is intended for research and analytical applications. 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu2+, Fe3+, Hg2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD).
    4-Aminohippuric acid (Standard)
  • HY-B1619S
    Cromolyn-d5 2140317-08-2
    Cromolyn-d5 (Cromoglycate-d5) is the deuterium labeled Cromolyn (HY-B1619). Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects.
    Cromolyn-d5
  • HY-N0682R
    Pyridoxine (hydrochloride) (Standard) 58-56-0
    Pyridoxine (hydrochloride) (Standard) is the analytical standard of Pyridoxine (hydrochloride). This product is intended for research and analytical applications. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
    Pyridoxine (hydrochloride) (Standard)
  • HY-N12670
    Egg oil 8001-17-0 ≥99.0%
    Egg oil is a natural oil, which consists primarily of cholesterol, lecithin and glycerides of the fatty acids. Egg oil exhibits activity in regulating the gut microbial dysbiosis, alleviating obesity, insulin resistance and inflammation.
    Egg oil
  • HY-N1414A
    3′,6-Disinapoylsucrose 76656-80-9
    3′,6-Disinapoylsucrose is a type of oligosaccharide that's effective when taken orally, and it has antidepressant, anti-anxiety, and antioxidant properties. 3′,6-Disinapoylsucrose inhibits neuronal apoptosis by lowering the ratio of Bax to Bcl-2 in hippocampal neurons, and it enhances cognitive function in APP/PS1 transgenic mice by activating the CREB/BDNF signaling pathway.
    3′,6-Disinapoylsucrose
  • HY-N1424R
    Glycoursodeoxycholic acid (Standard) 64480-66-6
    Glycoursodeoxycholic acid (Standard) is the analytical standard of Glycoursodeoxycholic acid. This product is intended for research and analytical applications. Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.
    Glycoursodeoxycholic acid (Standard)
  • HY-P3037A
    Imperatoxin A TFA 98.65%
    Imperatoxin A TFA is a peptide toxin derived from the venom of the African scorpion Pandinus imperator. Imperatoxin A TFA is a Ca2+-release channels/ryanodine receptors (RyRs) activator. Imperatoxin A TFA enhances the influx of Ca2+ from the sarcoplasmatic reticulum into the cell.
    Imperatoxin A TFA
  • HY-P3877A
    (Leu31,Pro34)-Peptide YY (human) (TFA) 99.96%
    (Leu31,Pro34)-Peptide YY (human) (TFA) is the TFA form of (Leu31,Pro34)-Peptide YY (human) (HY-P3877). (Leu31,Pro34)-Peptide YY (human) (TFA) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y1 agonist with a KD of 1.0 nM.
    (Leu31,Pro34)-Peptide YY (human) (TFA)
  • HY-P5119A
    Tat-peptide control 168-189 TFA
    Tat-peptide 168-189 is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 168-189 of rat G3BP1. Tat sequence from HIV, is placed at the least conserved end of the sequence, for cell permeability. Tat-peptide 168-189 is the negtive control of Tat-peptide 168-189 TFA (HY-P5118A), as Tat-peptide 168-189 TFA increases axon growth and increases the number of neurites per neuron.
    Tat-peptide control 168-189 TFA
  • HY-U00015
    MAO-IN-1 124991-40-8 ≥99.0%
    MAO-IN-1 is a monoamine oxidase B (MAO B) inhibitor with an IC50 of 20 nM.
    MAO-IN-1
  • HY-U00076
    MK-0249 862309-06-6 99.53%
    MK-0249 (Compound 1) is a potent, selective and orally active histamine H3 receptor antagonist, with an IC50 of 1.7 nM for human H3.
    MK-0249
  • HY-U00101
    Octazamide 56391-55-0 99.07%
    Octazamide (ICI-US 457) is an analgesic agent.
    Octazamide
  • HY-U00185
    A-437203 220519-06-2 99.08%
    A-437203 is a selective D3 receptor antagonist with Ki of 71, 1.6, and 6220 nM for D2, D3, and D4 receptors, respectively.
    A-437203
  • HY-U00325
    11β-HSD1-IN-1 1203956-47-1 99.80%
    11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1), with an IC50 of 52 nM, and used for the treatment of pain.
    11β-HSD1-IN-1
  • HY-Y0511R
    N,N-Dimethylglycine (Standard) 1118-68-9
    N,N-Dimethylglycine (Dimethylglycine) (Standard) is the analytical standard of N,N-Dimethylglycine (HY-Y0511). This product is intended for research and analytical applications. N,N-Dimethylglycine (Dimethylglycine), a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine has antidepressant-like and surfactant effects.
    N,N-Dimethylglycine (Standard)
  • HY-101321A
    Immepip dihydrobromide 164391-47-3 99.89%
    Immepip dihydrobromide is a H3 agonist. Immepip dihydrobromide can reduce cortical histamine release. Immepip dihydrobromide can be used for the research of neurological diseases.
    Immepip dihydrobromide
Cat. No. Product Name / Synonyms Application Reactivity